What if a therapy worked like a computer inside a cell?
See how we built a drug to reprogram liver cancer in mice.
The ability to program a therapy to make nuanced treatment decisions in single cells and address diseases at their root cause will greatly improve patient outcomes and create massive value for the healthcare system
We compute inside human cells using transcription factors, microRNAs, promoters and enhancers. Many of these inputs are key disease drivers that are generally undruggable with conventional small molecule or biologic therapies. Leveraging these inputs to drive treatment decisions in individual cells unlocks our ability to treat diseases at their root cause.
Ample knowledge exists about which molecules can efficiently eliminate or reprogram cells. However, these molecules are often very toxic on their own and cannot be administered to patients systemically. In combination with Pattern's precision molecular programs, they can be used as therapeutic effectors in a safe manner.
Our systematic design process generates therapeutic candidates at shorter timescales, reduced cost, and higher probability of success.
Pattern's approach has the potential to generate tailored cancer therapies that will eradicate tumors without causing significant adverse effects. This will unlock their use in early-stage cancer treatment as an alternative to surgery.
Pattern BioSciences mission is made possible by some of the most revolutionary.....
Keller Rinaudo Cliffton
Founder and CEO of Zipline